Effects of different surgical procedures on immunity of children with obstructive sleep apnea hypopnea syndrome / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To explore the effects of pure adenoidectomy,adenoidectomy with partial tonsillectomy,and adenoidectomy with total tonsillectomy on humoral and cellular immunity of children with OSAHS.@*METHOD@#The children with OSAHS diagnosed by polysomnography were divided into pure adenoidectomy group(group A),adenoidectomy with partial tonsillectomy group(group B), and adenoidectomy with total tonsillectomy(group C), and there were 50 cases in each group. The serum IgG, IgA, IgM level and peripheral blood T cell subgroup per-centage were detected at 6 months preoperatively and postoperatively. Tonsil grading and polysomnography wereconducted, recording symptoms improvement situation at postoperative 6 months.@*RESULT@#There was no statisticallysignificant difference compared with preoperative(P>0. 05) in humoral immunity and cellular immunity index ofpostoperative 6 months. There was no significani difference(P>C. 05) in curative effect among three groups in the 6th month post-operatively.@*CONCLUSION@#All of these three surgical procedures had no obvious effect on humoral orcellular immune function in children, and could effectively treat children OSAHS.

Hypothermia plasma ablation combination with adenoidectomy for treatment of sleep apnea syndrome / 局解手术学杂志

Objective To compare the clinical effects of low-temperature plasma ablation combined with adenoidectomy and decolle-ment in the treatment for patients with sleep apnea syndrome.Methods Totally 68 patients with sleep apnea syndrome who underwent elec-tive surgical treatment in our hospital from June 2013 to February 2015 were selected as the study objects.According to the order of treat-ment,the patients were randomly divided into the control group and the observation group,with 34 cases in each group.The control group were treated by routine decollement.The observation group were treated by low-temperature plasma ablation combined with adenoidectomy.After operation,the 2 groups were followed up for 6 months.The improvement effects of different operative methods in clinical symptoms and prog-nosis of patients with sleep apnea syndrome were compared.Results The total effective rate in the observation group (97.06%)was higher than that in the control group (82.35%),and the difference was statistically significant (P <0.05).The postoperative VAS pain grading of the observation group was relatively lower.The normal proportion (50.00%) was significantly higher than that in the control group (11.76%).Patients with moderate and severe pain in the control group accounted for 44.12% and 14.71% respectively,which were signif-icantly higher than those in the observation group(P <0.05).The incidence of postoperative bleeding in the observation group(2.94%)was significantly lower than that in the control group while the incidence of fever was higher than that in the control group (P <0.05).After oper-ation and at the end of the follow-up,OSA-18 score of the observation group decreased significantly and were (46.66 ±7.87)and (33.47 ± 10.59)respectively.The decreased range was greater than those in the control group (P <0.05).Conclusion To adopt low-temperature plasma radiofrequency ablation combined with adenoidectomy in the treatment of patients with sleep apnea syndrome can improve the surgical treatment effect,reduce postoperative pain,reduce the incidence of postoperative bleeding,optimize patients’quality of life and improve the prognosis.

Effect of intermittent hypoxia of sleep apnea on embryonic rat cortical neurons in vitro / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To investigate the effects of different pattens of intermittent hypoxia on the activity and apoptosis of primary cultured rat embryonic cortical neurons, and to evaluate the role of intermittent hypoxia in the mechanism of obstructive sleep syndrom induced cognitive function loss.@*METHOD@#The embryonic cerebral cortical neurons were cultured in vitro and were identified by immunofluorescence. Cultured neurons were randomly divided into intermittent hypoxia group, intermittent normal oxygen group, persistent hypoxia group and the control group, and intermittent hypoxia group was divided into five subgroups according to different frequency and time-bound. Neurons were exposed in different modes of hypoxia. MTT colorimetry was used to detect the viability of the neurons, and DAPI colorated measurement was used to calculate the percentages of neuron apoptosis.@*RESULT@#There were significantly different effects between all subgroups of intermittent hypoxia and the continued hypoxia group on neuronal activity and apoptosis (P 0.05).@*CONCLUSION@#The effect of intermittent hypoxia was more serious than that of continued hypoxia on neuronal activity and apoptosis; The impact of intermittent hypoxia on neuronal activity and apoptosis may be an important factor in obstructive sleep apnea related cognitive impairment.

The relationship between the abnormal behavior and serum C-reactive protein in children with obstructive sleep apnea-hypopnea syndrome / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To explore the pathogenesis of abnormal behavior in children with obstructive sleep apnea-hypopnea syndrome (OSAHS).@*METHOD@#The behavioral problems and C-reactive protein were measured in 40 children with OSAHS and 30 children with habitual snoring who underwent overnight Polysomnography, 40 cases of healthy children for the control group.@*RESULT@#The ratio of abnormal behavior in OSAHS and habitual snoring children was significantly higher than that of the healthy control group, while no significant difference between the two groups. The content of C-reactive protein in OSAHS children (4.24 mg/L) was significantly higher than habitual snoring (2.76 mg/L) and healthy control group (1.27 mg/L); in habitual snoring children C-reactive protein was higher than in healthy control group. The content of serum C-reactive protein in OSAHS children accompanied by abnormal behavior (4.63 mg/L) was significantly higher than that without abnormal behavior (3.23 mg/L). The content of serum C-reactive protein content in habitual snoring children accompanied by abnormal behavior (3.63 mg/L) was significantly higher than that without abnormal behavior (1.76 mg/L).@*CONCLUSION@#OSAHS and habitual snoring children have more behavior problems. C-reactive protein levels are higher in children with OSAHS and habitual snoring, and the levels of C-reactive protein are related to the abnormal behavior in these children.

The relationship between the abnormal behavior and serum C-reactive protein in children with obstructive sleep apnea-hypopcea syndrom / 临床耳鼻咽喉头颈外科杂志

Objective:To explore the pathogenesis of abnormal behavior in children with obstructive sleep apnea-hypopnea syndrome(OSAHS).Method:The behavioral problems and C-reactive protein were measured in 40 children with OSAHS and 30 children with habitual snoring who underwent overnight Polysomnography,40 cases of healthy children for the control group.Result:The ratio of abnormal behavior in OSAHS and abitual snoring children was significantly higher than that of the healthy control group,while no significant difference between the two groups.The content of C-reactive protein in OSAHS children(4.24 mg/L)was significantly higher than habitual snoring(2.76mg/L)and healthy control group(1.27mg/L);in habitual snoring children C-reactive protein was higher than in healthy control group.The content of serum C-reactive protein in OSAHS children accompanied by abnormal behavior(4.63 mg/L)was significantly higher than that without abnormal behavior(3.23 mg/L).The content of serum C-reactive protein content in habitual snoring children accompanied y abnormal behavior (3.63 mg/L)was significantly higher than that without abnormal behavior(1.76 mg/L).Conclusion:OSAHS and habitual snoring children have more behavior problems.C-reactive protein levels are higher in children with OSAHS and habitual snoring.and the levels of C-reactive protein are related to the abnormal ehavior in these children.

Clinical and polysomnographic characteristics in elderly patients with obstructive sleep apnea hypopnea syndrome / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To realize the characteristics of clinical symptoms and PSG in elderly patients with obstructive sleep apnea hypopnea syndrome (OSAHS).@*METHOD@#The clinical presentations, epworth sleepiness scale (ESS) and polysomnography findings were compared between elderly patients with OSAHS and middle age patients with OSAHS.@*RESULT@#There were no significantly differences in clinical presentations including snoring, apnea and daytime sleepiness complaint between the elderly and middle aged patients with OSAHS, but the incidences of complications such as hypertension and other cardiovascular diseases was significantly higher in elderly patients than those in the middle aged patients (P<0.01). The sleep architecture disturbance was significantly worse in elderly OSAHS patients compared with the middle age patients. The percentages of non-rapid eye movement (NREM) stage I sleep were significantly increased, the rapid eye movement (REM) sleep were significantly decreased in elderly OSAHS patients than those in middle aged group (P<0.01 or P<0.05), but the percentages of awake, NREM stage II sleep and NREM stage II-IV sleep had no significantly difference in the two groups. The apnea hypopnea index (AHI), apnea index (AI), hypopnea index (HI), snoring index, ESS and body mass index (BMI) were significantly decreased, the lowest oxygen saturation (LSO2) and micro-arousal index were significantly increased in elderly OSAHS patients than those in middle aged group (P<0.01 or P<0.05).@*CONCLUSION@#The elderly OSAHS patients are less sever than the middle age, but the elderly patients have worse sleep architecture disturbance and more complications such as hypertension and other cardiovascular diseases.

Prevalence Survey on Cyclospora cayetanensis and Cryptosporidium ssp. in Diarrhea Cases in Yunnan Province / 中国寄生虫学与寄生虫病杂志

Objective To investigate the prevalence and distribution characteristics of Cyclospora cayetanensis and Cryptosporidium ssp. infection in diarrhea cases of Yunnan Province. Methods To collect fresh faeces from diarrhea cases in 7 counties/cities, examine the specimens by direct smear with iodine staining and modified acid-fast staining. Results The infection rate of C. cayetanensis and Cryptosporidium ssp. was 3.97% and 5.29%, respectively. The infection rate of the two pathogenic coccidians was as high as 10.64% and 8.51% in preschool children. C. cayetanensis was found in 3 counties and Cryptosporidium in 6 counties. Conclusion Both C. cayetanensis and Cryptosporidium ssp. are prevalent in Yunnan Province with the latter distributed more widely, and the two pathogens are more prevalent in preschool children.